the Wilms tumor which is a childhood malignancy of the kidney.
A genetic mutation is acquired in a single body cell. And the surprising fact is that it is more likely to occur in the sperm than in the ovum. A larger number of cell divisions are involved in the production of sperm.
Genetic mutations may also occur in a single cell within an early embryo or a zygote. As all the cells divide during growth and development, the human will have some cells with the mutation and some cells without the genetic change. This situation is called mosaicism.
If a genetic mutation is involved, what was once an abnormality may become so common in certain populations that it emerges as the norm.
Five to 10% of cancer cases are hereditary cancers that are caused by genetic mutations. What is responsible for the 90-95% of cancers is another type of genetic mutation which is known as somatic mutation.